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HRID859547

反应详情

EQUATION

反应方程式

HRID 859547 的结构方程式

REACTANTS

反应物

3
结构：O=C(O)C(F)(F)F
HCID6422

未命名化合物

结构：CC(C)(C)OC(=O)Nc1ccc(C#Cc2ccc(F)cc2)cc1N
HCID69486641

未命名化合物

结构：CCOC(=O)CC(=O)c1cccc(-n2cnnn2)c1
HCID69592791

未命名化合物

PRODUCTS

生成物

1
结构：O=C1CC(c2cccc(-n3cnnn3)c2)=Nc2ccc(C#Cc3ccc(F)cc3)cc2N1
HCID9845127

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Prepared from [2-amino-4-(4-fluoro-phenylethynyl)-phenyl]-carbamic acid tert.-butyl ester (Example G33) and 3-oxo-3-(3-tetrazol-1-yl-phenyl)-propionic acid ethyl ester (Example H15) according to the general procedure K. The obtained material was deprotected and cyclized by treatment with TFA in CH2Cl2 according to the general procedure M. Obtained as a beige powder (5.5 mg).