Trifluoroacetic acid → HCID 9841907, compound

HRID 859558Notes

Reaction equation

HRID 859558 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]#[C:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:10][C:9]=1[NH:22][C:23](=[O:35])[CH2:24][C:25]([C:27]1[CH:32]=[CH:31][N:30]=[C:29]([C:33]#[N:34])[CH:28]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[O:35]=[C:23]1[CH2:24][C:25]([C:27]2[CH:32]=[CH:31][N:30]=[C:29]([C:33]#[N:34])[CH:28]=2)=[N:7][C:8]2[CH:13]=[CH:12][C:11]([C:14]#[C:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:10][C:9]=2[NH:22]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86588052HCID 86588052, compound

Product 1

HCID 9841907HCID 9841907, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared from {2-[3-(2-cyano-pyridin-4-yl)-3-oxo-propionylamino]-4-phenylethynyl-phenyl}-carbamic acid tert.-butyl ester (Example K67) by treatment with TFA in CH2Cl2 according to the general procedure M. Obtained as a yellow solid (10 mg).

Sources & evidence

ORD record
ord-44213bf386da42969fecc2ccee5ba6a7
Source dataset
uspto-grants-2006_12
Patent number
US07151098B2

Reaction notes

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