Trifluoroacetic acid → 4-Fluoro-3-[7-(2-fluoro-phenyl)-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl]-benzonitrile

HRID 859563Notes

Reaction equation

HRID 859563 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[F:20])=[CH:10][C:9]=1[NH:21][C:22](=[O:35])[CH2:23][C:24]([C:26]1[CH:31]=[C:30]([C:32]#[N:33])[CH:29]=[CH:28][C:27]=1[F:34])=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[F:34][C:27]1[CH:28]=[CH:29][C:30]([C:32]#[N:33])=[CH:31][C:26]=1[C:24]1[CH2:23][C:22](=[O:35])[NH:21][C:9]2[CH:10]=[C:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[F:20])[CH:12]=[CH:13][C:8]=2[N:7]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86588057{3-[3-(5-Cyano-2-fluoro-phenyl)-3-oxo-propionylamino]-2'-fluoro-biphenyl-4-yl}-carbamic acid tert.-butyl ester

Product 1

HCID 222249524-Fluoro-3-[7-(2-fluoro-phenyl)-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl]-benzonitrile

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared from {3-[3-(5-cyano-2-fluoro-phenyl)-3-oxo-propionylamino]-2′-fluoro-biphenyl-4-yl}-carbamic acid tert.-butyl ester (Example K72) by treatment with TFA in CH2Cl2 according to the general procedure M. Obtained as a yellow solid (92 mg).

Sources & evidence

ORD record
ord-3ce3162bba1d46d2a83b37fdec82d429
Source dataset
uspto-grants-2006_12
Patent number
US07151098B2

Reaction notes

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