Trifluoroacetic acid → HCID 22224841, compound

HRID 859600Notes

Reaction equation

HRID 859600 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]#[C:15][C:16]2[CH:21]=CC(F)=[CH:18][CH:17]=2)=[CH:10][C:9]=1[NH:23][C:24](=[O:36])[CH2:25][C:26]([C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([C:34]#[N:35])[CH:29]=1)=O)(C)(C)C.[C:38](O)([C:40]([F:43])(F)F)=O>C(Cl)Cl>[F:43][C:40]1[CH:38]=[CH:21][C:16]([C:15]#[C:14][C:11]2[CH:12]=[CH:13][C:8]3[N:7]=[C:26]([C:28]4[CH:29]=[C:30]([CH:31]=[CH:32][CH:33]=4)[C:34]#[N:35])[CH2:25][C:24](=[O:36])[NH:23][C:9]=3[CH:10]=2)=[CH:17][CH:18]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86601096HCID 86601096, compound

Product 1

HCID 22224841HCID 22224841, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared from [2-[3-(3-cyano-phenyl)-3-oxo-propionylamino]-4-(4-fluoro-phenylethynyl)-phenyl]-carbamic acid tert.-butyl ester (Example K98) (307 mg, 0.62 mmol) by treatment with TFA in CH2Cl2 according to the general procedure M. Obtained as a eggshell solid (146 mg).

Sources & evidence

ORD record
ord-268bfc0d12ce45a48d35faa2f1f9fd0b
Source dataset
uspto-grants-2006_12
Patent number
US07151098B2

Reaction notes

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