HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 1-Methyl-2-nitro-4-propoxybenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Nitro-p-cresol | HCID 16271 | — |
| Reactant | 1-Iodopropane | HCID 33643 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-Methyl-2-nitro-4-propoxybenzene | HCID 58764279 | — |
Reaction Steps
Potassium carbonate (13.5 g, 0.098 mol) followed by 1-iodopropane (9.56 mL, 0.098 mol) were added to a solution of 4-methyl-3-nitro-phenol (15 g, 0.098 mol) in DMF (100 mL). The mixture was stirred for 5 hours and then partitioned between H2O and EtOAc. The organic layer was washed with satd NaHCO3, brine, dried over Na2SO4 and concentrated to a clear oil (17.5 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07151105B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-8a04233435bd4c2ab60daa3e952937d7 |
| Source note | uspto-grants-2006_12 |