反应详情

温度

45 °C

To a solution of 4-bromo-1-bromomethyl-2-ethyl-benzene (2.0 g, 7.25 mmol) in DMF/H2O (30 mL/6 mL) was added potassium cyanide (471 mg, 7.25 mmol). The reaction mixture was heated to 45° C. for 3 hours before it was cooled to room temperature. The mixture was diluted with Et2O and washed with H2O, brine and dried over MgSO4. The solvent was removed in vacuo to obtain the desired product (1.33 g, 80% yield). 1H NMR (300 MHz, CDCl3): δ 1.26 (t, J=7.5 Hz, 3 H), 2.60–2.67 (m, 2 H), 3.66 (s, 2H), 7.23–7.26 (m, 1H), 7.35–7.36 (m, 1 H), 7.38–7.40 (m, 1H).

1. temperaturewas cooled to room temperature
2. washwashed with H2O, brine
3. dry with materialdried over MgSO4
4. customThe solvent was removed in vacuo