Methylhydrazine → HCID 67042357, compound

This compound was prepared by a modification of a reported procedure (J. Het Chem. 1975, 12, 855): A 2-L, 3-necked round bottom flask was charged with 2-cyanopyridine (40 g, 0.384 mol), methylhydrazine (93.7 g, 5.3 equiv, 2.035 mol), and ethanol (200 mL). The reaction was stirred under N2, overnight at room temperature. An additional equiv of hydrazine was added (6.3 equiv cumulative total in reaction mixture) and stirred for an additional 2–3 h at room temperature. The EtOH and excess hydrazine were distilled off in vacuo to afford a yellow crystalline solid. The yellow solid was triturated with benzene, affording a slurry of white crystals. The crystals were filtered, washed with a minimal amount of benzene and dried overnight in a vacuum oven at 50° C. The reaction yielded 41.33 g (71.6%) of the product as white crystals. 1H NMR (300 MHz, CDCl3): δ 2.97 (s, 3H), 4.02 (br s, 1H), 5.30 (br s, 1H), 7.20 (m, 1H), 7.66 (m, 1H), 8.08 (m, 1H), 8.45 (m, 1H). MS (APCI) calcd for C7H10N4: 150.09, found (M+H+): 151.3

1. customThis compound was prepared by a modification of a reported procedure (J. Het Chem. 1975, 12, 855)
2. custom(6.3 equiv cumulative total in reaction mixture)
3. stirringstirred for an additional 2–3 h at room temperature
4. distillationThe EtOH and excess hydrazine were distilled off in vacuo
5. customto afford a yellow crystalline solid
6. customThe yellow solid was triturated with benzene
7. customaffording a slurry of white crystals
8. filtrationThe crystals were filtered
9. washwashed with a minimal amount of benzene
10. customdried overnight in a vacuum oven at 50° C

ORD record

ord-813efa6fd6814a45b32592c50c640144

Source dataset

uspto-grants-2006_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07151105B2