反应详情

温度

25 °C

To a stirred solution of 2-{2-chloro-4-[2-(2-cyclopentyl-4,6-dioxo-tetrahydro-pyran-2-yl)-ethyl]-phenyl}-2-methyl-propionitrile (0.5 g, 1.29 mmol) from step 5 of example B(22), and p-acetamidobenzenesulfonyl azide (0.46 g, 1.94 mmol) in THF (4 mL) under argon was added TEA (0.54 mL, 3.87 mmol). The resulting solution was stirred at 25° C. overnight. The solvents were removed and the residue was purified by flash column chromatography (25–60% % EtOAc in hexanes) to give the product as a yellow oil. ESIMS (MH+): 414.

1. customThe solvents were removed
2. customthe residue was purified by flash column chromatography (25–60% % EtOAc in hexanes)