Hydrochloric Acid → 1-Methyl-3-(6-methylpyridin-2-yl)-1H-1,2,4-triazole-5-carbaldehyde hydrochloride hydrate

HRID 859744Notes

Reaction equation

HRID 859744 reaction equation
C([O:3][CH:4](OCC)[C:5]1[N:9]([CH3:10])[N:8]=[C:7]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([CH3:17])[N:12]=2)[N:6]=1)C.[ClH:21]>O>[OH2:3].[ClH:21].[CH3:10][N:9]1[C:5]([CH:4]=[O:3])=[N:6][C:7]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([CH3:17])[N:12]=2)=[N:8]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 587642202-[5-(Diethoxymethyl)-1-methyl-1H-1,2,4-triazol-3-yl]-6-methylpyridine

Product 1

HCID 866053711-Methyl-3-(6-methylpyridin-2-yl)-1H-1,2,4-triazole-5-carbaldehyde hydrochloride hydrateYield 189.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent3×

Procedure

A mixture of 2-[5-(diethoxymethyl)-1-methyl-1H-1,2,4-triazol-3-yl]-6-methylpyridine (38 g, 0.1377 mol), water (92 mL) and concentrated HCl (23 mL, 0.276 mol) was heated at 70–80° C. for 2 h. The resulting solution was co-evaporated with water four times using a water aspirator vacuum, then dried in vacuo at 60° C. to give 33.5 g (94.5%) of the title product as a covalently-bound hydrate. Satisfactory C,H,N-analysis was obtained. 1H NMR (400 MHz, D2O+TFA): δ 2.90 (s, 3H), 4.13 (s, 3H), 6.38 (s, 1H), 7.94 (d, J=8 Hz, 1H), 8.37 (d, J=8 Hz, 1H), 8.56 (t, J=8 Hz, 1H). LC-MS (API-ES) calcd for C10H10N4O: 202.09, found (M+H+): 203.1; (M+18+H+) 221.1 m/z.

Workup

  1. temperaturewas heated at 70–80° C. for 2 h
  2. customdried in vacuo at 60° C.

Sources & evidence

ORD record
ord-d7c29b1b2d2b4f00a06d64c50ea0b7bb
Source dataset
uspto-grants-2006_12
Patent number
US07151105B2

Reaction notes

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