Carbon Dioxide → HCID 10942638, compound

Temperature

100 °C

Acetonedicarboxylic acid (Aldrich, 165115) (60 g, 0.41 mol) was added rapidly to propionic anhydride (Aldrich, 240311) (170 mL, 1.3 mol) containing concentrated sulfuric acid (2 mL), and the reaction mixture was heated at 100° C. for 30 minutes with stirring. The solution was cooled rapidly in an ice-salt mixture, and just when a white solid mass was forming, the reaction was added to cold water (500 mL), stirred and filtered immediately. The product was air-dried and placed in a 3 L flask and treated with aqueous 10% sodium carbonate (600 mL). The resulting paste was stirred with a stirrer and heated at 100° C. for 30 min. Carbon dioxide evolved and a light yellow solution was obtained which was heated at 85–90° C. for further 80 min. The solution was cooled and acidified with aqueous 30% acetic acid until no more carbon dioxide was evolved. The white precipitate was filtered, washed with water, air-dried and then added to concentrate hydrochloric acid (120 mL) in a 2 L round-bottomed flask, and the mixture was heated under reflux for 4 hours. The solution was cooled in ice and neutralized by adding it to a stirred solution of sodium carbonate (about 115 g) in water (about 500 mL). The neutral solution was extracted thoroughly with EtOAc. The extract was dried and stripped of solvent to give product 2,6-Diethyl-4-pyrone as a brown oil. (Yates et al, JOC, vol. 34, No, 12, 1969, p4046–4052)

1. customwas forming
2. stirringstirred
3. filtrationfiltered immediately
4. customThe product was air-dried
5. customplaced in a 3 L flask
6. additiontreated with aqueous 10% sodium carbonate (600 mL)
7. stirringThe resulting paste was stirred with a stirrer
8. temperatureheated at 100° C. for 30 min
9. customa light yellow solution was obtained which
10. temperaturewas heated at 85–90° C. for further 80 min
11. temperatureThe solution was cooled
12. filtrationThe white precipitate was filtered
13. washwashed with water
14. customair-dried
15. additionadded
16. concentrationto concentrate hydrochloric acid (120 mL) in a 2 L round-bottomed flask
17. temperaturethe mixture was heated
18. temperatureunder reflux for 4 hours
19. temperatureThe solution was cooled in ice
20. additionby adding it to a stirred solution of sodium carbonate (about 115 g) in water (about 500 mL)
21. extractionThe neutral solution was extracted thoroughly with EtOAc
22. customThe extract was dried

ORD record

ord-ca3573cb241d4efcba258952e3bb5d61

Source dataset

uspto-grants-2006_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07151105B2