Potassium Iodide → HCID 11161144, Verbindung

HRID 859844Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 859844
[CH:1]1([N:4]([C:6]2[CH:11]=[C:10]([F:12])[C:9]([F:13])=[CH:8][C:7]=2[OH:14])[CH3:5])[CH2:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+].[I-].[K+].Cl[CH2:24][C:25](=[O:27])[CH3:26]>CC(C)=O>[CH:1]1([N:4]([C:6]2[CH:11]=[C:10]([F:12])[C:9]([F:13])=[CH:8][C:7]=2[O:14][CH2:24][C:25](=[O:27])[CH3:26])[CH3:5])[CH2:2][CH2:3]1

Komponenten

6

Edukt 4

HCID 4875Potassium IodideHCID 6571ChloroacetoneHCID 11430Potassium CarbonateHCID 11298566HCID 11298566, Verbindung

Produkt 1

HCID 11161144HCID 11161144, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

53 mg of 2-(N-cyclopropyl-N-methylamino)-4,5-difluorophenol, 44 mg of potassium carbonate, 6.4 mg of potassium iodide and 0.03 ml of chloroacetone are mixed in 1 ml of acetone and are heated at reflux for 20 h. The mixture is then evaporated and the residue is taken up in diethyl ether and washed with water. The organic phase is dried with magnesium sulfate and evaporated to dryness, and the residue is purified by flash chromatography. 1-[2-(N-Cyclopropyl-N-methylamino)-4,5-difluorophenoxy]propan-2-one is thus obtained as a yellow oil.

Aufarbeitung

  1. temperatureare heated
  2. temperatureat reflux for 20 h
  3. customThe mixture is then evaporated
  4. washwashed with water
  5. dry with materialThe organic phase is dried with magnesium sulfate
  6. customevaporated to dryness
  7. customthe residue is purified by flash chromatography

Quellen und Nachweise

ORD-Eintrag
ord-833fd754a3dd410bb3c14533d0a4311d
Quelldatensatz
uspto-grants-2006_12
Patentnummer
US07153814B2

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