Potassium Iodide → HCID 11161144, compound

Participants

Reaction Steps

53 mg of 2-(N-cyclopropyl-N-methylamino)-4,5-difluorophenol, 44 mg of potassium carbonate, 6.4 mg of potassium iodide and 0.03 ml of chloroacetone are mixed in 1 ml of acetone and are heated at reflux for 20 h. The mixture is then evaporated and the residue is taken up in diethyl ether and washed with water. The organic phase is dried with magnesium sulfate and evaporated to dryness, and the residue is purified by flash chromatography. 1-[2-(N-Cyclopropyl-N-methylamino)-4,5-difluorophenoxy]propan-2-one is thus obtained as a yellow oil.

Provenance & Evidence