反应详情

温度

100 °C

(3R,4R)-1-Benzyloxycarbonyl-3-hydroxy-4-methanesulfonyloxymethylpyrrolidine (125 mg) was dissolved in N,N-dimethylformamide (3 mL) and sodium azide (50.0 mg) was added. The mixture was stirred at 100° C. for 1 hour and was then concentrated under reduced pressure. The resulting residue was dissolved in ethyl acetate (5 mL) and the solution was washed with water (2×1 mL), followed by drying over anhydrous sodium sulfate and concentration under reduced pressure. The resulting residue was purified on a silica gel column (eluant=ethyl acetate) to give 91.0 mg of (3R,4R)-3-azidomethyl-1-benzyloxycarbonyl-4-hydroxypyrrolidine as a milky white syrup-like product. The compound was identical to the compound obtained by Process (A).

1. concentrationwas then concentrated under reduced pressure
2. dissolutionThe resulting residue was dissolved in ethyl acetate (5 mL)
3. washthe solution was washed with water (2×1 mL)
4. dry with materialby drying over anhydrous sodium sulfate and concentration under reduced pressure
5. customThe resulting residue was purified on a silica gel column (eluant=ethyl acetate)