Formic Acid → N-(2-Fluorophenyl)formamide
Reaction equation
[CH:1]([OH:3])=O.C(OC(=O)C)(=O)C.[F:11][C:12]1[CH:18]=[CH:17][CH:16]=[CH:15][C:13]=1[NH2:14]>O1CCCC1>[F:11][C:12]1[CH:18]=[CH:17][CH:16]=[CH:15][C:13]=1[NH:14][CH:1]=[O:3]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 50 °C
Procedure
Under argon gas, at 0° C., formic acid (6.1 ml) was dropped to acetic anhydride (15.5 ml), which was stirred at 50° C. for 2 hours. The reaction solution was left up to room temperature, and diluted with tetrahydrofuran (10 ml). At room temperature, tetrahydrofuran (20 ml) solution containing 2-fluoroaniline (5.56 g) added to the above solution, which was stirred at room temperature for 1 hour. The reaction solution was concentrated to give a title compound having the following physical properties. The obtained title compound was used for the following reaction without further purification.
Workup
- waitThe reaction solution was left up to room temperature
- additionadded to the above solution, which
- stirringwas stirred at room temperature for 1 hour
- concentrationThe reaction solution was concentrated
Sources & evidence
- ORD record
- ord-300bae363042400a83173b8563e2b122
- Source dataset
- uspto-grants-2006_12
- Patent number
- US07153852B2
Reaction notes
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