Acetyl chloride → HCID 10343002, compound

HRID 859908Notes

Reaction equation

HRID 859908 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][CH2:17][NH:18][S:19]([CH:22]3[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]3)(=[O:21])=[O:20])[CH2:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=1.[C:28](Cl)(=[O:30])[CH3:29]>ClCCl>[CH:22]1([S:19]([NH:18][CH2:17][CH2:16][CH2:15][CH2:14][N:11]2[CH2:12][CH2:13][N:8]([C:4]3[CH:3]=[C:2]([NH:1][C:28](=[O:30])[CH3:29])[CH:7]=[CH:6][CH:5]=3)[CH2:9][CH2:10]2)(=[O:21])=[O:20])[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 11682666HCID 11682666, compound

Product 1

HCID 10343002HCID 10343002, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Reaction of cyclohexanesulfonic acid {4-[4-(3-amino-phenyl)-piperazin-1-yl]-butyl}-amide and acetyl chloride in dichloromethane as described in Example 3 gave the desired product, N-{3-[4-(4-Cyclohexanesulfonylamino-butyl)-piperazin-1-yl]-phenyl}-acetamide, as a white solid.

Sources & evidence

ORD record
ord-916884686e6c4ae0ae482239a46f8ce4
Source dataset
uspto-grants-2006_12
Patent number
US07153858B2

Reaction notes

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