Ammonium Chloride → Pyridazine-3-carboximidamide
Reaction equation
[Na].[N:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]#[N:9])[N:3]=1.[Cl-].[NH4+:11]>CO>[N:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]([NH2:11])=[NH:9])[N:3]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 35 °C
Procedure
A solution of 1.60 g (0.068 mol) of sodium in 300 ml of anhydrous methanol was treated with a solution of 53.5 g (0.510 mol) of pyridazine-3-carbonitrile in 100 ml of methanol and the mixture was stirred for 8 hours at 35° C. Then, 29 g of ammonium chloride were added and the mixture was refluxed for approximately 14 hours. The hot mixture was filtered and the solid was discarded. 53.3 g of the title compound were obtained from the cold mother liquor by means of filtration.
Workup
- temperaturethe mixture was refluxed for approximately 14 hours
- filtrationThe hot mixture was filtered
Sources & evidence
- ORD record
- ord-264db5ed6cbc4e3f9c5a47aa76802f11
- Source dataset
- uspto-grants-2006_12
- Patent number
- US07153860B2
Reaction notes
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