反应详情

A stirred solution of Ethyl-2-[(methylsulfonyl)amino]-4-methyl-thiazole-5-carboxylate (300 mg, 1.14 mmol) in methanol (9 mL) was treated with a 1N NaOH solution (28.4 mL, 28.4 mmol). The mixture was stirred at rt overnight. The solution was cooled to 0° C. and acidified with 6N aq. HCl solution to pH 1. The solution was extracted with dichloromethane-chloroform mixture. The organic extract was dried (MgSO4), filtered and concentrated in vacuo to obtain the title acid (148 mg, 55%).

1. temperatureThe solution was cooled to 0° C.
2. extractionThe solution was extracted with dichloromethane-chloroform mixture
3. extractionThe organic extract
4. dry with materialwas dried (MgSO4)
5. filtrationfiltered
6. concentrationconcentrated in vacuo
7. customto obtain the title acid (148 mg, 55%)