1-(4-Methoxyphenyl)piperazine → HCID 69605030, compound

HRID 860003Notes

Reaction equation

HRID 860003 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[CH:5][CH:4]=1.BrC1C=CC(S(O[CH2:26][C@@H:27]2[O:41][C:31]3=[C:32]4[C:37](=[CH:38][CH:39]=[C:30]3[O:29][CH2:28]2)[N:36]=[C:35]([CH3:40])[CH:34]=[CH:33]4)(=O)=O)=CC=1>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([N:9]2[CH2:14][CH2:13][N:12]([CH2:26][C@@H:27]3[O:41][C:31]4=[C:32]5[C:37](=[CH:38][CH:39]=[C:30]4[O:29][CH2:28]3)[N:36]=[C:35]([CH3:40])[CH:34]=[CH:33]5)[CH2:11][CH2:10]2)=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 2697221-(4-Methoxyphenyl)piperazineHCID 20624762[(2R)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl4-bromobenzenesulfonate

Product 1

HCID 69605030HCID 69605030, compoundYield 84%

Procedure

This compound was prepared as described for Example 5, using 4-methoxyphenyl piperazine (880 mg, 4.58 mmol) and 742 mg (1.65 mmol) of [(2R)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl 4-bromobenzene-sulfonate, to afford 560 mg (84%) of the title compound as a white solid: mp 164–165° C.; MS (ESI) m/z406 [M+H]+.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-fdc8dfab31c14a62914e2cacf34d0e19
Source dataset
uspto-grants-2006_12
Patent number
US07153849B2

Reaction notes

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