1-(3,4-Xylyl)piperazine → HCID 69605050, compound

HRID 860005Notes

Reaction equation

HRID 860005 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[CH3:8].BrC1C=CC(S(O[CH2:26][C@@H:27]2[O:41][C:31]3=[C:32]4[C:37](=[CH:38][CH:39]=[C:30]3[O:29][CH2:28]2)[N:36]=[C:35]([CH3:40])[CH:34]=[CH:33]4)(=O)=O)=CC=1>>[CH3:1][C:2]1[CH:3]=[C:4]([N:9]2[CH2:10][CH2:11][N:12]([CH2:26][C@@H:27]3[O:41][C:31]4=[C:32]5[C:37](=[CH:38][CH:39]=[C:30]4[O:29][CH2:28]3)[N:36]=[C:35]([CH3:40])[CH:34]=[CH:33]5)[CH2:13][CH2:14]2)[CH:5]=[CH:6][C:7]=1[CH3:8]

Participants

3

Reactant 2

HCID 27237821-(3,4-Xylyl)piperazineHCID 20624762[(2R)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl4-bromobenzenesulfonate

Product 1

HCID 69605050HCID 69605050, compoundYield 68%

Procedure

This compound was prepared as described for Example 10, using 1-(3,4-dimethylphenyl)-piperazine (1.01 g, 5.33 mmol), and 804 mg (1.79 mmol) of [(2R)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl 4-bromobenzene-sulfonate, to afford 404 mg (68%) of the title compound as a white foam: mp 118–120° C.; MS (ESI) m/z404 [M+H]+.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-7461092f065940f48de564cc5d2398e0
Source dataset
uspto-grants-2006_12
Patent number
US07153849B2

Reaction notes

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