反应详情

A solution of 6-fluoroquinoline 1-oxide from Step B (5.0 g, 30.65 mmol) in acetic anhydride (30 mL) is heated at 110° C. for 6.5 hours. The reaction is allowed to stand at room temperature overnight. The solid (1.1 g) is collected and recrystallized from anhydrous ethanol (75 mL). The reddish crystals are collected by filtration and dried under high vacuum to give the title compound (0.653 g), m.p. dec. 269–270° C.

1. customThe solid (1.1 g) is collected
2. customrecrystallized from anhydrous ethanol (75 mL)
3. filtrationThe reddish crystals are collected by filtration
4. customdried under high vacuum