HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 6-Fluoro-1,2-dihydroquinolin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 6-Fluoro-1-oxo-1lambda~5~-quinoline | HCID 19898646 | — |
| Product | 6-Fluoro-1,2-dihydroquinolin-2-one | HCID 9834043 | — |
Reaction Steps
A solution of 6-fluoroquinoline 1-oxide from Step B (5.0 g, 30.65 mmol) in acetic anhydride (30 mL) is heated at 110° C. for 6.5 hours. The reaction is allowed to stand at room temperature overnight. The solid (1.1 g) is collected and recrystallized from anhydrous ethanol (75 mL). The reddish crystals are collected by filtration and dried under high vacuum to give the title compound (0.653 g), m.p. dec. 269–270° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07153849B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-426482cb18f346cc95904b856e8a76d2 |
| Source note | uspto-grants-2006_12 |