Hydrochloric Acid → 2,6-Diamino-4-pyrimidinepentanoic acid

Participants

Reaction Steps

The ethyl ester 2-2 (190 mg, 0.8 mmol) in TBF (10 mL) and water (10 mL) was treated with 1 N NaOH (1.6 mL, 1.6 mmol). After stirring at room temperature for 16 hours, the solution was neutralized with 1N HCl and then the solvents removed in vacuo. The residue, 2-3, was used as such in the next step.

Provenance & Evidence