Hydrochloric Acid → 2,6-Diamino-4-pyrimidinepentanoic acid

HRID 860042Notes

Reaction equation

HRID 860042 reaction equation
C([O:3][C:4](=[O:17])[CH2:5][CH2:6][CH2:7][CH2:8][C:9]1[N:14]=[C:13]([NH2:15])[N:12]=[C:11]([NH2:16])[CH:10]=1)C.[OH-].[Na+].Cl>O>[NH2:15][C:13]1[N:12]=[C:11]([NH2:16])[CH:10]=[C:9]([CH2:8][CH2:7][CH2:6][CH2:5][C:4]([OH:17])=[O:3])[N:14]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 58765530HCID 58765530, compound

Product 1

HCID 234355042,6-Diamino-4-pyrimidinepentanoic acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The ethyl ester 2-2 (190 mg, 0.8 mmol) in TBF (10 mL) and water (10 mL) was treated with 1 N NaOH (1.6 mL, 1.6 mmol). After stirring at room temperature for 16 hours, the solution was neutralized with 1N HCl and then the solvents removed in vacuo. The residue, 2-3, was used as such in the next step.

Workup

  1. customthe solvents removed in vacuo

Sources & evidence

ORD record
ord-2ec3758f5a8f4e978a0d956753218445
Source dataset
uspto-grants-2006_12
Patent number
US07153862B2

Reaction notes

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