HCID 69666214, compound → HCID 69666423, compound

HRID 860063Notes

Reaction equation

HRID 860063 reaction equation
[CH2:1]([O:3][C:4](=[O:43])[CH2:5][CH:6]([C:33]1[CH:34]=[N:35][C:36]2[C:41]([CH:42]=1)=[CH:40][CH:39]=[CH:38][CH:37]=2)[CH:7]=[CH:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]1[N:18]=[C:17]([NH:19][C:20](=[O:25])[C:21]([CH3:24])([CH3:23])[CH3:22])[N:16]=[C:15]([NH:26][C:27](=[O:32])[C:28]([CH3:31])([CH3:30])[CH3:29])[CH:14]=1)[CH3:2]>CCO>[CH2:1]([O:3][C:4](=[O:43])[CH2:5][CH:6]([C:33]1[CH:34]=[N:35][C:36]2[C:41]([CH:42]=1)=[CH:40][CH:39]=[CH:38][CH:37]=2)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]1[N:18]=[C:17]([NH:19][C:20](=[O:25])[C:21]([CH3:24])([CH3:23])[CH3:22])[N:16]=[C:15]([NH:26][C:27](=[O:32])[C:28]([CH3:29])([CH3:30])[CH3:31])[CH:14]=1)[CH3:2]

Participants

3

Reactant 1

HCID 69666214HCID 69666214, compound

Product 1

HCID 69666423HCID 69666423, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The alkene 7-7 (1.02 g, 1.74 mmol) was dissolved in EtOH (50 mL) and degassed with argon. Palladium on carbon (10%; 100 mg) was added and the mixture stirred under an atmosphere of hydrogen gas (balloon) for 3 hours. The mixture was filtered through celite and the solvent removed to give the title compound 7-8 which was used as such in the next step.

Workup

  1. customdegassed with argon
  2. additionPalladium on carbon (10%; 100 mg) was added
  3. filtrationThe mixture was filtered through celite
  4. customthe solvent removed

Sources & evidence

ORD record
ord-37432d75052b49548fff0b5992029725
Source dataset
uspto-grants-2006_12
Patent number
US07153862B2

Reaction notes

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