反应详情

To a solution of 6-7 (42.8 g, 102 mmol) and 2-methyl-pyrimidine-5-carbaldehyde (12.45 g, 102 mmol) in THF (250 mL) at 0° was added 4M NaOH (26.7 mL, 107 mmol) dropwise. After 15 minutes the ice bath was removed and the mixture stirred for an additional 10 minutes. The solution was diluted with water, extracted with ethyl acetate, and dried (Na2SO4). Following concentration, the residue was triturated with ether to give 27.7 g (61%) of 16-1 as a white solid.

1. customAfter 15 minutes the ice bath was removed
2. additionThe solution was diluted with water
3. extractionextracted with ethyl acetate
4. dry with materialdried (Na2SO4)
5. concentrationconcentration
6. customthe residue was triturated with ether