4-Iodo-2-methylpyridine → HCID 69120171, compound

HRID 860152Notes

Reaction equation

HRID 860152 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[CH:13]=[C:12]([C:14]#[CH:15])[N:11]=[C:10]2[CH3:16])[CH:5]=[CH:6][C:7]=1[Cl:8].I[C:18]1[CH:23]=[CH:22][N:21]=[C:20]([CH3:24])[CH:19]=1>>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[CH:13]=[C:12]([C:14]#[C:15][C:18]3[CH:23]=[CH:22][N:21]=[C:20]([CH3:24])[CH:19]=3)[N:11]=[C:10]2[CH3:16])[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

3

Reactant 2

HCID 126913224-Iodo-2-methylpyridineHCID 85997994HCID 85997994, compound

Product 1

HCID 69120171HCID 69120171, compound

Procedure

4-[1-(3,4-Dichloro-phenyl)-2-methyl-1H-imidazol-4-ylethynyl]-2-methyl-pyridine hydrochloride (2) [MS: m/e=341.9 (M+H+)] was prepared in analogy to the method as described in Example 1 Method B starting from 1-(3,4-dichloro-phenyl)-4-ethynyl-2-methyl-1H-imidazole (IV-2) and 4-iodo-2-methyl-pyridine. For further purification the compound was precipitated as its HCl salt from an etheral solution. Method C:

Workup

  1. customFor further purification the compound
  2. customwas precipitated as its HCl salt from an etheral solution

Sources & evidence

ORD record
ord-d216625d266d481e80d1264618039543
Source dataset
uspto-grants-2006_12
Patent number
US07153874B2

Reaction notes

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