HCID 10335523, compound → HCID 10063685, compound

HRID 860157Notes

Reaction equation

HRID 860157 reaction equation
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([N:8]2[CH:12]=[C:11]([C:13]#[C:14][C:15]3[CH:20]=[CH:19][N:18]=[C:17]([CH3:21])[CH:16]=3)[N:10]=[C:9]2[CH3:22])[N:3]=1.[CH3:23][O-:24].[Na+]>CO>[CH3:23][O:24][C:2]1[CH:7]=[N:6][CH:5]=[C:4]([N:8]2[CH:12]=[C:11]([C:13]#[C:14][C:15]3[CH:20]=[CH:19][N:18]=[C:17]([CH3:21])[CH:16]=3)[N:10]=[C:9]2[CH3:22])[N:3]=1

Participants

4

Reactant 2

HCID 10335523HCID 10335523, compoundHCID 10942334Sodium Methoxide

Product 1

HCID 10063685HCID 10063685, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound, MS: m/e=306.5 (M+H+) was prepared by treatment of 100 mg 0.32 mmol) 2-chloro-6-[2-methyl-4-(2-methyl-pyridin-4-ylethynyl)-imidazol-1-yl]-pyrazine (27) with 5 equiv. of sodium methoxide in 4 ml of methanol (3 h, 55° C.). The compound, after extraction with ethyl acetate/water, was purified by chromatography. Yield: 62 mg (0.203 mmol, 63%).

Sources & evidence

ORD record
ord-be862029d968443b951919a54238c410
Source dataset
uspto-grants-2006_12
Patent number
US07153874B2

Reaction notes

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