Sodium Hydroxide → n-(4-Carbamimidoyl-phenyl)-2-phenyl-malonamic acid sodium salt

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Reaction Steps

8.26 g (19.5 mmol) of the benzyl ester from example 1 were dissolved in 100 ml THF and stirred overnight with 20 ml 2 M aqueous NaOH. The solvent was removed after filtration, water was added, and the solution extracted with diethyl ether. The aqueous phase was freeze dried and sufficiently pure for further derivatization.

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