Sodium Hydroxide → n-(4-Carbamimidoyl-phenyl)-2-phenyl-malonamic acid sodium salt

HRID 860178Notes

Reaction equation

HRID 860178 reaction equation
C([O:8][C:9](=[O:29])[CH:10]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:11]([NH:13][C:14]1[CH:19]=[CH:18][C:17]([C:20](=[NH:22])[NH2:21])=[CH:16][CH:15]=1)=[O:12])C1C=CC=CC=1.[OH-].[Na+:31]>C1COCC1>[Na+:31].[C:20]([C:17]1[CH:16]=[CH:15][C:14]([NH:13][C:11](=[O:12])[CH:10]([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[C:9]([O-:29])=[O:8])=[CH:19][CH:18]=1)(=[NH:21])[NH2:22]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 10110753HCID 10110753, compound

Product 1

HCID 23700157n-(4-Carbamimidoyl-phenyl)-2-phenyl-malonamic acid sodium salt

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

8.26 g (19.5 mmol) of the benzyl ester from example 1 were dissolved in 100 ml THF and stirred overnight with 20 ml 2 M aqueous NaOH. The solvent was removed after filtration, water was added, and the solution extracted with diethyl ether. The aqueous phase was freeze dried and sufficiently pure for further derivatization.

Workup

  1. customThe solvent was removed
  2. filtrationafter filtration, water
  3. additionwas added
  4. extractionthe solution extracted with diethyl ether
  5. customdried and sufficiently pure for further derivatization

Sources & evidence

ORD record
ord-80021ebbbb5a4ec49a4f9333d7dfcb19
Source dataset
uspto-grants-2006_12
Patent number
US07153876B2

Reaction notes

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