反应详情

8.26 g (19.5 mmol) of the benzyl ester from example 1 were dissolved in 100 ml THF and stirred overnight with 20 ml 2 M aqueous NaOH. The solvent was removed after filtration, water was added, and the solution extracted with diethyl ether. The aqueous phase was freeze dried and sufficiently pure for further derivatization.

1. customThe solvent was removed
2. filtrationafter filtration, water
3. additionwas added
4. extractionthe solution extracted with diethyl ether
5. customdried and sufficiently pure for further derivatization