反应详情

A mixture of 2-benzoylcyclohexanone (1.00 g), sodium ethoxide (404 mg) in ethanol (5 mL) was stirred for 3.5 hours at room temperature. The reaction was quenched by adding 1N hydrochloric acid (1 mL). The solvent was evaporated off, and the residue was partitioned between ethyl acetate and water. The organic layer was washed with brine, dried over magnesium sulfate, and evaporated to give ethyl 7-oxo-7-phenylheptanoate as a brown oil (1.33 g).

1. customThe reaction was quenched
2. additionby adding 1N hydrochloric acid (1 mL)
3. customThe solvent was evaporated off
4. customthe residue was partitioned between ethyl acetate and water
5. washThe organic layer was washed with brine
6. dry with materialdried over magnesium sulfate
7. customevaporated