反应详情

To a solution of dimethyl 2-bromoterephthalate (1.04 g) in methanol (10 mL) was added 1 N sodium hydroxide (5.71 mL) at room temperature. After stirring for 1.5 hour, the reaction was quenched by adding 1 N hydrochloric acid (7 mL). White crystals were formed. Water (10 mL) was added to aid crystalyzation. The crystals were collected by filtration, washed with water, and dried in the air. 3-Bromo-4-(methoxycarbonyl)benzoic acid was obtained as white crystals (532 mg).

1. customthe reaction was quenched
2. additionby adding 1 N hydrochloric acid (7 mL)
3. customWhite crystals were formed
4. filtrationThe crystals were collected by filtration
5. washwashed with water
6. customdried in the air