HCID 68802434, compound → HCID 69309153, compound

HRID 860506Notes

Reaction equation

HRID 860506 reaction equation
[CH2:1]([C:3]1[N:7]2[N:8]=[C:9]([CH3:27])[C:10]([CH2:20][CH2:21][CH2:22][CH2:23][C:24]([OH:26])=[O:25])=[C:11]([C:12]3[CH:17]=[CH:16][N:15]=[C:14]([CH:18]=[CH2:19])[CH:13]=3)[C:6]2=[CH:5][CH:4]=1)[CH3:2].[H][H]>CO.[Pd]>[CH2:1]([C:3]1[N:7]2[N:8]=[C:9]([CH3:27])[C:10]([CH2:20][CH2:21][CH2:22][CH2:23][C:24]([OH:26])=[O:25])=[C:11]([C:12]3[CH:17]=[CH:16][N:15]=[C:14]([CH2:18][CH3:19])[CH:13]=3)[C:6]2=[CH:5][CH:4]=1)[CH3:2]

Participants

5

Reactant 2

HCID 68802434HCID 68802434, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 69309153HCID 69309153, compoundYield 92.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 5-[7-ethyl-2-methyl-4-(2-vinyl-4-pyridinyl)pyrrolo[1,2-b]pyridazin-3-yl]pentanoic acid (15 mg) in MeOH was added 10% Pd/C (2 mg). The mixture was stirred under under hydrogen atomosphere (1 atm) for 6 h. The reaction mixture was filtered through Celite and the filtrate was concentrarted in vacuo. The residue was triturated with hexane to give 5-[7-ethyl-4-(2-ethyl-4-pyridinyl)-2-methylpyrrolo[1,2-b]pyridazin-3-yl]pentanoic acid (14 mg) as an yellow solid.

Workup

  1. filtrationThe reaction mixture was filtered through Celite
  2. customThe residue was triturated with hexane

Sources & evidence

ORD record
ord-17af261910224b0eb9ca25e17970f44c
Source dataset
uspto-grants-2006_12
Patent number
US07153854B2

Reaction notes

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