Hydrochloric Acid → HCID 9895120, compound

Participants

Reaction Steps

(4-{1-[4-[2-(2-Chloro-6-fluoro-phenyl)-ethyl]-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-ethylsulfan yl}-2-methyl-phenoxy)-acetic acid ethyl ester (30 mg) is taken into THF (0.5 mL and treated with LiOH (1.0 N, 0.5 mL for 2 hrs. The reaction mixture is acidified with 5 N HCl, extracted with ethyl ether, dried over sodium sulfate. Concentration gave the title compound. MS (ES): 610.1 (M++1, 35Cl), 612.1 (M++1, 37Cl), the structure is also confirmed by proton NMR.

Provenance & Evidence