Hydrochloric Acid → HCID 9895120, compound

HRID 860660Notes

Reaction equation

HRID 860660 reaction equation
C([O:3][C:4](=[O:42])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([S:13][CH:14]([C:16]2[S:20][C:19]([C:21]3[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][CH:22]=3)=[N:18][C:17]=2[CH2:31][CH2:32][C:33]2[C:38]([F:39])=[CH:37][CH:36]=[CH:35][C:34]=2[Cl:40])[CH3:15])=[CH:9][C:8]=1[CH3:41])C.[Li+].[OH-].Cl>C1COCC1>[Cl:40][C:34]1[CH:35]=[CH:36][CH:37]=[C:38]([F:39])[C:33]=1[CH2:32][CH2:31][C:17]1[N:18]=[C:19]([C:21]2[CH:22]=[CH:23][C:24]([C:27]([F:29])([F:30])[F:28])=[CH:25][CH:26]=2)[S:20][C:16]=1[CH:14]([S:13][C:10]1[CH:11]=[CH:12][C:7]([O:6][CH2:5][C:4]([OH:42])=[O:3])=[C:8]([CH3:41])[CH:9]=1)[CH3:15]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 69356322HCID 69356322, compound

Product 1

HCID 9895120HCID 9895120, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

(4-{1-[4-[2-(2-Chloro-6-fluoro-phenyl)-ethyl]-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-ethylsulfan yl}-2-methyl-phenoxy)-acetic acid ethyl ester (30 mg) is taken into THF (0.5 mL and treated with LiOH (1.0 N, 0.5 mL for 2 hrs. The reaction mixture is acidified with 5 N HCl, extracted with ethyl ether, dried over sodium sulfate. Concentration gave the title compound. MS (ES): 610.1 (M++1, 35Cl), 612.1 (M++1, 37Cl), the structure is also confirmed by proton NMR.

Workup

  1. extractionextracted with ethyl ether
  2. dry with materialdried over sodium sulfate
  3. concentrationConcentration

Sources & evidence

ORD record
ord-defcc57b1f204e5e81c66cd57b172ecd
Source dataset
uspto-grants-2006_12
Patent number
US07153878B2

Reaction notes

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