Dichloromethane → 3-[(3-chlorophenyl)-piperidin-3-ylmethoxy]-N-methylpropanamide

HRID 86069Notes

Reaction equation

HRID 86069 reaction equation
[Cl:1][c:2]1[cH:3][c:4]([CH:8]([CH:9]2[CH2:10][N:11]([C:15]([O:16][C:17]([CH3:18])([CH3:19])[CH3:20])=[O:21])[CH2:12][CH2:13][CH2:14]2)[O:22][CH2:23][CH2:24][C:25](=[O:26])[NH:27][CH3:28])[cH:5][cH:6][cH:7]1.[Cl:36][CH2:37][Cl:38].[F:29][C:30]([F:31])([F:32])[C:33]([OH:34])=[O:35]>>[Cl:1][c:2]1[cH:3][c:4]([CH:8]([CH:9]2[CH2:10][NH:11][CH2:12][CH2:13][CH2:14]2)[O:22][CH2:23][CH2:24][C:25](=[O:26])[NH:27][CH3:28])[cH:5][cH:6][cH:7]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 68715501Tert-butyl 3-[(3-chlorophenyl)-[3-(methylamino)-3-oxopropoxy]methyl]piperidine-1-carboxylate

Product 1

HCID 687113793-[(3-chlorophenyl)-piperidin-3-ylmethoxy]-N-methylpropanamide

Sources & evidence

ORD record
ord-2227c924d5e541c9945c73b43feac165
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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