Hydrochloric Acid → HCID 69376388, compound

Participants

Reaction Conditions

Reaction Steps

To 3-aminobenzenesulphonamide (172 mg, 1.0 m.mol) in 1,4-dioxane (8 ml) was added 2-Chloro-4-[(2-Morpholino)anilino]pyrimidine (290 mgs, 1 m.mol) and hydrogen chloride (4.0M solution in 1,4-dioxane, 50 μl). The mixture was heated at 100° C. for 60 hrs. The reaction mixture was cooled, the resulting solid filtered, washed with 1,4-dixane and dried (in vacuo at 48° C.) to give pale brown solid (358 mg). Rt 5.88; MS (M+H)+: 427.

Provenance & Evidence