Hydrochloric Acid → HCID 69376388, compound

HRID 860760Notes

Reaction equation

HRID 860760 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([S:8]([NH2:11])(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.Cl[C:13]1[N:18]=[C:17]([NH:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[N:26]2[CH2:31][CH2:30][O:29][CH2:28][CH2:27]2)[CH:16]=[CH:15][N:14]=1.Cl>O1CCOCC1>[S:8]([C:4]1[CH:3]=[C:2]([CH:7]=[CH:6][CH:5]=1)[NH:1][C:13]1[N:18]=[C:17]([NH:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[N:26]2[CH2:27][CH2:28][O:29][CH2:30][CH2:31]2)[CH:16]=[CH:15][N:14]=1)(=[O:9])(=[O:10])[NH2:11]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 7377Benzenesulfonamide, 3-amino-HCID 85769707HCID 85769707, compound

Product 1

HCID 69376388HCID 69376388, compoundYield 84.2%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
100 °C

Procedure

To 3-aminobenzenesulphonamide (172 mg, 1.0 m.mol) in 1,4-dioxane (8 ml) was added 2-Chloro-4-[(2-Morpholino)anilino]pyrimidine (290 mgs, 1 m.mol) and hydrogen chloride (4.0M solution in 1,4-dioxane, 50 μl). The mixture was heated at 100° C. for 60 hrs. The reaction mixture was cooled, the resulting solid filtered, washed with 1,4-dixane and dried (in vacuo at 48° C.) to give pale brown solid (358 mg). Rt 5.88; MS (M+H)+: 427.

Workup

  1. temperatureThe reaction mixture was cooled
  2. filtrationthe resulting solid filtered
  3. washwashed with 1,4-dixane and
  4. customdried (in vacuo at 48° C.)

Sources & evidence

ORD record
ord-d1e8559b08fc45e59e47903504be9289
Source dataset
uspto-grants-2006_12
Patent number
US07153964B2

Reaction notes

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