Sodium Azide → HCID 86591157, compound

HRID 860780Notes

Reaction equation

HRID 860780 reaction equation
Br[CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([C:20]2[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=2)([OH:19])[C:13]2[N:17]([CH3:18])[CH:16]=[N:15][CH:14]=2)=[CH:8][C:7]=1[C:27](=[O:35])[C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([Cl:34])[CH:29]=1)=[O:4].[N-:36]=[N+:37]=[N-:38].[Na+]>CO>[N:36]([CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([C:20]2[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=2)([OH:19])[C:13]2[N:17]([CH3:18])[CH:16]=[N:15][CH:14]=2)=[CH:8][C:7]=1[C:27](=[O:35])[C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([Cl:34])[CH:29]=1)=[O:4])=[N+:37]=[N-:38]

Participants

4

Reactant 2

HCID 33557Sodium AzideHCID 69019837HCID 69019837, compound

Product 1

HCID 86591157HCID 86591157, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of intermediate (4) (0.0161 mol) and NaN3 (0.0161 mol) in methanol (25 ml) was stirred and refluxed overnight.The product was used without further purification, yielding 2-azido-N-[2-(3-chlorobenzoyl)-4-[(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]phenyl]-acetamide (intermediate 5).

Workup

  1. temperaturerefluxed overnight
  2. customThe product was used without further purification

Sources & evidence

ORD record
ord-0accd08af5104bdca9787c8d0a78dea3
Source dataset
uspto-grants-2006_12
Patent number
US07153958B2

Reaction notes

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