HRID861010

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID176

Acetic Acid

C2H4O2

HCID8929

Sodium cyanide (Na(CN))

CNNa

结构：CC(C)(c1cc(-c2cccc(C=O)c2)c2ncccc2c1)S(C)(=O)=O

HCID10155043

未命名化合物

PRODUCTS

生成物

结构：COC(=O)c1cccc(-c2cc(C(C)(C)S(C)(=O)=O)cc3cccnc23)c1

HCID68887704

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID14801

Manganese oxide (Mn2O4)

MnO2

溶剂HCID21226129

未命名化合物

PROCEDURE

实验过程

To a solution of 3-[6-(1-methanesulfonyl-1-methyl-ethyl)-quinolin-8-yl]-benzaldehyde (1.0 eq.) (see WO-0146151) in CH2Cl2:MeOH (1:1; 0.1M) was added NaCN (1.8 eq.), MnO2 (8.0 eq.) and AcOH (0.05 eq.). The mixture was stirred for 12 h, filtered on celite, and concentrated. Flash chromatography (Hex:EtOAc; 1:1) afforded the title compound as a white solid.

WORKUP

后处理

filtrationfiltered on celite
concentrationconcentrated