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Acetic Acid → Methyl 3-{6-[1-methyl-1-(methylsulfonyl)ethyl]quinolin-8-yl}benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Sodium Cyanide | HCID 8929 | — |
| 反応物 | 3-{6-[1-Methyl-1-(methylsulfonyl)ethyl]-8-quinolinyl}benzaldehyde | HCID 10155043 | — |
| 触媒 | Manganese dioxide | HCID 14801 | — |
| 溶媒 | Dichloromethane methanol | HCID 21226129 | — |
| 生成物 | Methyl 3-{6-[1-methyl-1-(methylsulfonyl)ethyl]quinolin-8-yl}benzoate | HCID 68887704 | — |
反応手順
To a solution of 3-[6-(1-methanesulfonyl-1-methyl-ethyl)-quinolin-8-yl]-benzaldehyde (1.0 eq.) (see WO-0146151) in CH2Cl2:MeOH (1:1; 0.1M) was added NaCN (1.8 eq.), MnO2 (8.0 eq.) and AcOH (0.05 eq.). The mixture was stirred for 12 h, filtered on celite, and concentrated. Flash chromatography (Hex:EtOAc; 1:1) afforded the title compound as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07153968B2 |
| 出典データセット | uspto-grants-2006_12 |
| ORD ID | ord-df74200bd12f45dcbbe914ca65f97030 |
| 出典メモ | uspto-grants-2006_12 |