epsilon-CAPROLACTONE → Poliglecaprone

HRID 861177Notes

Reaction equation

HRID 861177 reaction equation
[C:1]1(=[O:8])[O:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:9]1[O:16][C:14](=[O:15])[CH2:13][O:12][C:10]1=[O:11]>C(O)(C(F)(F)F)C(F)(F)F>[C:1]1(=[O:8])[O:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:9]1[O:16][C:14](=[O:15])[CH2:13][O:12][C:10]1=[O:11]

Participants

4

Reactant 2

HCID 10401epsilon-CAPROLACTONEHCID 65432Glycolide

Product 1

HCID 65431Poliglecaprone

Reagents, catalysts & solvents 1

HCID 135291,1,1,3,3,3-Hexafluoro-2-propanolSolvent

Procedure

The procedure described in Example 1 is substantially reproduced by reacting 114.14 gm (1.0 mole) of ε-caprolactone with 116.07 gm (1.0 mole) of glycolide. A weigh loss of 0.6% is observed upon devolatilization. The I.V. of the copolymer is 1.92 dl/g in HFIP and PCL/PGA molar ratio of 49.5/50.5 by NMR.

Sources & evidence

ORD record
ord-e1708c40e6f44cf7aca1c674a846b384
Source dataset
uspto-grants-1998_02
Patent number
US05713920

Reaction notes

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