Dichloromethane → 4-{Bis[4-(trifluoromethoxy)phenyl]methyl}piperidin-4-ol
Reaction equation
[CH2:45]([Cl:46])[Cl:47].[F:1][C:2]([O:3][c:4]1[cH:5][cH:6][c:7]([CH:10]([C:11]2([OH:24])[CH2:12][CH2:13][N:14]([C:17]([O:18][C:19]([CH3:20])([CH3:21])[CH3:22])=[O:23])[CH2:15][CH2:16]2)[c:25]2[cH:26][cH:27][c:28]([O:31][C:32]([F:33])([F:34])[F:35])[cH:29][cH:30]2)[cH:8][cH:9]1)([F:36])[F:37].[F:38][C:39]([F:40])([F:41])[C:42]([OH:43])=[O:44]>>[F:1][C:2]([O:3][c:4]1[cH:5][cH:6][c:7]([CH:10]([C:11]2([OH:24])[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]2)[c:25]2[cH:26][cH:27][c:28]([O:31][C:32]([F:33])([F:34])[F:35])[cH:29][cH:30]2)[cH:8][cH:9]1)([F:36])[F:37]Participants
4
Sources & evidence
- ORD record
- ord-7f7d42cdb7cd416a91ed0b9f10011d5a
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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