反应详情

A mixture of 4,4'-dihydroxybenzophenone (12.4 g, 57.9 mmol), 2-chloromethylquinoline (23.4 g, 132 mmol) and cesium carbonate (46.0 g, 141.2 mmol) was stirred in dry DMF (170 mL). After 5 hours, saturated aqueous NaCl was added and the light brown solid formed was collected by filtration and washed with water. The solid was suspended in ether and collected by filtration, resuspended in ethanol and collected again by filtration and dried in vacuo to afford bis(4-(2-quinolylmethoxy)phenyl) ketone (27.3 g, 95%): IR (KBr) 1635, 1600, 1505, 1250 cm-1 ; 1H NMR (300 MHz, DMSO-d6)δ5.48 (s, 4H), 7.22 (d, 4H, J=9 Hz), 7.64 (m, 2H), 7.71 (d, 4H, J=9 Hz), 7.80 (m, 2H), 8.02 (m, 2H), 8.44 (d, 2H, J=8.5 Hz); MS (DCI/NH3) m/e: 497 (M+H)+.

1. customthe light brown solid formed
2. filtrationwas collected by filtration
3. washwashed with water
4. filtrationcollected by filtration
5. filtrationcollected again by filtration
6. customdried in vacuo