反应详情

A solution of 50.0 g (190 mmol) of 2-(phthalimido)acetaldehyde diethyl acetal in 300 mL of toluene was treated with 150 mL of 50% aqueous trifluoroacetic acid and the mixture was stirred vigorously at ambient temperature for 72 h. The solution was concentrated in vacuo and 100 mL of ethyl acetate was added. The white precipitate was filtered off and washed with ice-cold ethyl acetate (100 mL) to give 30.0 g (78%) of the title compound.

1. concentrationThe solution was concentrated in vacuo and 100 mL of ethyl acetate
2. additionwas added
3. filtrationThe white precipitate was filtered off
4. washwashed with ice-cold ethyl acetate (100 mL)