Water → HCID 178441768, compound

HRID 861544Notes

Reaction equation

[CH2:1]([C:5]1[NH:6][C:7]([C:20](OCC)=[O:21])=[C:8]([S:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=2)[N:9]=1)[CH2:2][CH2:3][CH3:4].CC(C[AlH]CC(C)C)C.O>C(Cl)Cl.C1(C)C=CC=CC=1>[CH2:1]([C:5]1[NH:9][C:8]([S:10][CH2:11][C:12]2[CH:13]=[CH:14][C:15]([O:18][CH3:19])=[CH:16][CH:17]=2)=[C:7]([CH2:20][OH:21])[N:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

Conditions

Temperature: -78 °C

Procedure

50 g or 143.5 mmol of ethyl 2-butyl-4-[4-methoxy-benzyl-thio]-1H-imidazole-5-carboxylate[prepared as indicated in the European Patent Application No. 0,465,368] were solubilized in 300 ml of methylene chloride and the mixture was cooled to -78° C. With stirring, 68.3 g (480 mmol) and 2N DIBAH in 400 ml of toluene were added and then the medium was allowed to return to ambient temperature for about 30 minutes. The reaction medium was hydrolyzed with 130 ml of water, filtered, washed with 500 ml of methylene chloride and then 3 times with 500 ml of a methylene chloride/methanol solution (9-1). After evaporation to dryness, 100 g (orange solid) were recovered and 500 ml of methylene chloride/methanol (9-2) were added. The insoluble white product was filtered off and the organic phase was evaporated to dryness to obtain 46.55 g of product (orange-yellow powder) which was purified on a silica column with methanol/methylene chloride (5-95) as eluant to obtain 32.49 g of the expected product.

Workup

filtrationfiltered
washwashed with 500 ml of methylene chloride
customAfter evaporation to dryness, 100 g (orange solid)
customwere recovered
addition500 ml of methylene chloride/methanol (9-2) were added
filtrationThe insoluble white product was filtered off
customthe organic phase was evaporated to dryness

Sources & evidence

ORD record: ord-5694a8164df4403c881975148785eaeb
Source dataset: uspto-grants-1998_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05714508

Reaction notes

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