Tranylcypromine, cis- → (+)-N-(cis-2-phenylcyclopropyl)-N'-(5-chloropyrid-2-yl)thiourea

HRID 861633Notes

Reaction equation

HRID 861633 reaction equation
[C:1]1([C@H:7]2[CH2:9][C@H:8]2[NH2:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:11][C:12]1[CH:13]=[CH:14][C:15]([NH:18][C:19](N2C=CN=C2)=[S:20])=[N:16][CH:17]=1>>[C:1]1([C@H:7]2[CH2:9][C@H:8]2[NH:10][C:19]([NH:18][C:15]2[CH:14]=[CH:13][C:12]([Cl:11])=[CH:17][N:16]=2)=[S:20])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 6971118Tranylcypromine, cis-HCID 10823879N-(5-Chloropyridin-2-yl)-1H-imidazole-1-carbothioamide

Product 1

HCID 22868897(+)-N-(cis-2-phenylcyclopropyl)-N'-(5-chloropyrid-2-yl)thiourea

Procedure

(-)-N-cis-2-phenylcyclopropylamine (0.23 g, 1.7 mmol) from Example 423 was condensed with 1-(5-chloropyrid-2-yl-thiocarbamoyl)-imidazole (0.4 g, 1.7 mmol) according to the procedure of Example 372 to yield the titled product as crystals.

Sources & evidence

ORD record
ord-5d280098060641eaa42fb6c1748f4c61
Source dataset
uspto-grants-1998_02
Patent number
US05714503

Reaction notes

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