Acetic Acid → tert-Butyl 4-[2-amino-4-(methoxycarbonyl)-phenyl]piperazine-1-carboxylate

HRID 86166Notes

Reaction equation

HRID 86166 reaction equation
[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][c:7]([N+:24]([O-:25])=[O:26])[c:8]([N:11]2[CH2:12][CH2:13][N:14]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[CH2:15][CH2:16]2)[cH:9][cH:10]1.[CH3:27][C:28](=[O:29])[OH:30].[Fe:39].[O:33]1[CH2:34][CH2:35][O:36][CH2:37][CH2:38]1.[OH2:31].[OH2:32]>>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][c:7]([NH2:24])[c:8]([N:11]2[CH2:12][CH2:13][N:14]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[CH2:15][CH2:16]2)[cH:9][cH:10]1

Participants

6

Reactant 5

HCID 176Acetic AcidHCID 962Water2×HCID 23925IronHCID 312751,4-DioxaneHCID 66598073Tert-butyl 4-[4-(methoxycarbonyl)-2-nitrophenyl]piperazine-1-carboxylate

Product 1

HCID 18526396tert-Butyl 4-[2-amino-4-(methoxycarbonyl)-phenyl]piperazine-1-carboxylate

Sources & evidence

ORD record
ord-778d4c7d51624414a2233868a97f2c39
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

Loading…