1-Methyl-1,2,3,6-tetrahydropyridin-1-ium-5-carboxylic acid;chloride → 1-methylpiperidine-3-carboxylic Acid

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Reaction Steps

Arecaidine hydrochloride (4 grams) (22.6 mmoles) was hydrogenated in water (100 ml) using 10% Pd--C at 40 psi at 25° C. for 24 hours. The catalyst was filtered off and washed with water. The aqueous solution was shaken with BioRad AG1X8 resin (OH- form) (23 ml bed) and after 5 minutes the resin was filtered off and washed with water. The aqueous solution was evaporated to give the title compound (Yield: 2.95 grams, 92%).

Provenance & Evidence