Dicyclohexylcarbodiimide → HCID 178455724, compound

HRID 861761Notes

Reaction equation

HRID 861761 reaction equation
C1(N=C=NC2CCCCC2)CCCCC1.[F:16][C:17]1[CH:18]=[C:19]([CH:23]=[C:24]([F:27])[C:25]=1[F:26])[C:20]([OH:22])=[O:21].[CH2:28]([C@H:30]1[CH2:35][CH2:34][C@H:33]([C:36]2[CH:41]=[CH:40][C:39](O)=[CH:38][CH:37]=2)[CH2:32][CH2:31]1)[CH3:29]>ClCCl>[F:16][C:17]1[CH:18]=[C:19]([CH:23]=[C:24]([F:27])[C:25]=1[F:26])[C:20]([O:22][C:39]1[CH:38]=[CH:37][C:36]([C@H:33]2[CH2:34][CH2:35][C@H:30]([CH2:28][CH3:29])[CH2:31][CH2:32]2)=[CH:41][CH:40]=1)=[O:21]

Participants

5

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 8531543,4,5-Trifluorobenzoic acidHCID 178455720HCID 178455720, compound

Product 1

HCID 178455724HCID 178455724, compoundYield 75.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.03 g (5.00 mmol) of dicyclohexylcarbodiimide, 0.88 g (5.00 mmol) of 3,4,5-trifluorobenzoic acid and 1.02 g (5.00 mmol) of 4-(trans-4-ethylcyclohexyl)phenol are stirred at room temperature for 6 hours with 10 mg of 4-N,N-dimethylaminopyridine in 30 ml of dichloromethane. Filtration, evaporation of the solvent and purification by chromatography (silica gel/hexane) give 1.36 g of product. ##STR21## Phase sequence: X 90 (59) N (72) I

Workup

  1. filtrationFiltration, evaporation of the solvent and purification by chromatography (silica gel/hexane)

Sources & evidence

ORD record
ord-3ad5cdbede294da0a11fcd342814bc6e
Source dataset
uspto-grants-1998_02
Patent number
US05716543

Reaction notes

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