反应详情

5 g (24.2 mmol) of 4,4-dimethyl-6-thiochromancarboxaldehyde, prepared in Example 11(a), and 50 ml of dichloromethane were introduced into a round-bottomed flask. 16.1 g (48.4 mmol) of carbon tetrabromide, 12.7 g (48.4 mmol) of triphenylphosphine and 3.16 g (48.4 mmol) of zinc powder were successively added and stirring was carried out at room temperature for two hours. The reaction mixture was evaporated and the residue obtained purified by chromatography on a silica column eluted with hexane. 7.75 g (88%) of the expected compound were recovered.

1. additionwere introduced into a round-bottomed flask
2. customThe reaction mixture was evaporated
3. customthe residue obtained
4. custompurified by chromatography on a silica column
5. washeluted with hexane
6. custom7.75 g (88%) of the expected compound were recovered